A multidisciplinary judging panel will recommend winners after evaluating submissions based on the following equally weighted criteria. Depending on the volume of submissions received, an expert panel may conduct an initial review of eligible submissions and determine a subset for judge evaluation.

Phase 1 evaluation criteria

Performance

The degree to which the entrant demonstrates that a solution can or will accurately diagnose an active Lyme disease infection. This includes the credibility of explanation and the level of expected performance with regard to specificity and sensitivity, with data to support.

Technical maturity

The degree to which the solution has been developed with a rigorous scientific rationale grounded in credible existing research, preliminary testing, or other relevant forms of validation. This includes demonstrating an understanding of Lyme disease diagnostics and offering a credible explanation for how the solution overcomes known technical challenges in the field.

Clinical impact

The potential for the solution to integrate into new or existing clinical protocols and maintain performance across a range of patient populations. This includes a well-developed plan to engage clinical and patient stakeholders.

Population impact

The potential for the solution to improve population health, including its proposed or demonstrated accessibility, the extent to which entrants address equity in the design and implementation plans, and the opportunity for public health impact through improved data and surveillance.

Viability

The extent to which the entrant outlines an aggressive yet achievable development process, including a detailed development plan for prototyping, iteration, testing/validation, and evaluation of the diagnostic test(s) in future phases of the Competition and/or beyond, including a consideration of potential risks or unintended consequences.

Sustainability

The degree to which the entrant demonstrates scalability potential and provides a credible long-term plan for regulatory viability, market entry, business need, and the development of the test as a real-world product.

Innovation

The novelty and uniqueness of the solution, as well as its potential to advance the field of Lyme disease diagnostics and treatment as a whole, including opportunities to advance scientific understanding of Lyme disease spirochetes through contributions to the existing evidence base.